2013

MCD, CDAA

NASH,非酒精性脂肪肝

Masahiko Matsumoto*, Natsuko Hada?, Yoshiyuki Sakamaki*, Akiko Uno*, Toshihiko Shiga?,Chiaki Tanaka?, Tsuneo Ito?, Asao Katsume? and Masayuki Sudoh. An improved mouse model that rapidly develops fibrosis in non-alcoholic steatohepatitis. Int. J. Exp. Path. (2013), 94, 93–103

2009

MCD, MCS

NASH,非酒精性脂肪肝

Angela Dolganiuc, Jan Petrasek, Karen Kodys, Donna Catalano, Pranoti Mandrekar,Arumugam Velayudham, and Gyongyi Szabo.MicroRNA Expression Profile in Lieber-DeCarli Diet-Induced Alcoholic and Methionine Choline Deficient Diet-Induced Nonalcoholic Steatohepatitis Models in Mice. Alcohol Clin Exp Res. 2009 Oct;33(10):1704-10

2018

MCD

NASH,非酒精性脂肪肝

Alshammari GM, Balakrishnan A,Chinnasamy T. Protective role of germinated mung bean against progression of non-alcoholic steatohepatitis in rats: A dietary therapy to improve fatty liver health. J Food Biochem. 2018;e12542

2018

MCD

NAFLD,非酒精性脂肪肝

Ghedeir M. Alshammari，Aristatile Balakrishnan，Thirunavukkarasu Chinnasamy. Butein protects the nonalcoholic fatty liver through mitochondrial reactive oxygen species attenuation in rats. Biofactors. 2018 Apr 19. doi: 10.1002/biof.1428.

2018

MCD

NASH,非酒精性脂肪肝

Du J, et al., Neonatal overfeeding in mice aggravates the development of methionine and cholinedeficient
diet-induced steatohepatitis in adulthood, Genes & Diseases (2017), https://doi.org/10.1016/j.gendis.2017.12.008

2016

MCD

NASH,非酒精性脂肪肝

Park HS1, Jang JE, Ko MS, Woo SH, Kim BJ, Kim HS, Park HS, Park IS, Koh EH, Lee KU.Statins Increase Mitochondrial and Peroxisomal Fatty Acid Oxidation in the Liver and Prevent Non-Alcoholic Steatohepatitis in Mice.Diabetes Metab J. 2016 Oct;40(5):376-385

2016

MCD, HFHS

NASH,非酒精性脂肪肝

Reid DT, Reyes JL, McDonald BA, Vo T,Reimer RA, Eksteen B (2016) Kupffer Cells Undergo Fundamental Changes during the Development ofExperimental NASH and Are Critical in Initiating Liver Damage and Inflammation. PLoS ONE 11(7):e0159524. doi:10.1371/journal.pone.0159524

2016

CDAA, CSAA

NASH,非酒精性脂肪肝

A. Takeuchi-Yorimoto et al. MicroRNA-21 is associated with fibrosis in a rat model of nonalcoholic steatohepatitis and serves as a plasma biomarker for fibrotic liver disease.Toxicology Letters 258 (2016) 159–167

2016

MCD， MCS

NASH,非酒精性脂肪肝

Anika L. Dzierlenga, John D. Clarke, David M. Klein, Tarun Anumol, Shane A. Snyder HongYu Li, and Nathan J. Cherrington. Biliary Elimination of Pemetrexed Is Dependent on Mrp2 in Rats: Potential Mechanism of Variable Response in Nonalcoholic Steatohepatitis.J Pharmacol Exp Ther 358:246–253, August 2016

2016

MCD， MCS

NASH,非酒精性脂肪肝

A. L. Dzierlenga, J. D. Clarke, and N. J. Cherrington.Nonalcoholic Steatohepatitis Modulates Membrane Protein Retrieval
and Insertion Processes.Drug Metab Dispos 44:1799–1807, November 2016

2016

MCD, AIN93G

NAFLD,非酒精性脂肪肝

L Zhang, P Krishnan, DJ Ehresman…. Perfluorooctane Sulfonate-Choline Ion Pair Formation: A Potential Mechanism Modulating Hepatic Steatosis and Oxidative Stress in Mice. TOXICOLOGICAL SCIENCES, 153(1), 2016, 186–197

2016

MCD， MCS

NASH,非酒精性脂肪肝

T Laho, JD Clarke, AL Dzierlenga, H Li….Effect of nonalcoholic steatohepatitis on renal filtration and secretion of adefovir. Biochemical Pharmacology 115 (2016) 144–151

2016

MCD, AIN93G, HF60

NASH,非酒精性脂肪肝

Y Lee, SG Lee, CJ Lee, SH Kim, YM Song, MR Yoon…. Association between betatrophin/ANGPTL8 and non-alcoholic fatty liver disease: animal and human studies. Sci Rep. 2016 Apr 5;6:24013. doi: 10.1038/srep24013.

2016

MCD， MCS

NASH,非酒精性脂肪肝

MA Wells, KC Vendrov, ML Edin, BC Ferslew….Characterization of the Cytochrome P450 epoxyeicosanoid pathway in non-alcoholic steatohepatitis.Prostaglandins Other Lipid Mediat. 2016 September ; 125: 19–29. doi:10.1016/j.prostaglandins. 2016.07.002.

2016

CDAA

NASH,非酒精性脂肪肝

A Eguchi, XDM Du Jeu….Liver Bid-suppression for treatment of fibrosis associated with nonalcoholic steatohepatitis. J Hepatol. 2016 March ; 64(3): 699–707. doi:10.1016/j.jhep.2015.11.002.

2016

HFHC (180724)

NAFLD,非酒精性脂肪肝

P Puri, J Xu, T Vihervaara, R Katainen, K Ekroos…. Alcohol produces distinct hepatic lipidome and eicosanoid signature in lean and obese. Alcohol produces distinct hepatic lipidome and eicosanoid signature in lean and obese

2016

CDAA, CSAA

NASH,非酒精性脂肪肝

W Liu, D Struik, VJM Nies…. Effective treatment of steatosis and steatohepatitis by fibroblast growth factor 1 in mouse models of nonalcoholic fatty liver disease. Proc Natl Acad Sci U S A. 2016 Feb 23;113(8):2288-93. doi: 10.1073/pnas.1525093113. Epub 2016 Feb 8.

2016

CDAA, CSAA

NASH,非酒精性脂肪肝,HCC，肝癌

N Yamamoto, T Yamasaki, T Takami…. Deferasirox, an oral iron chelator, prevents hepatocarcinogenesis and adverse effects of sorafenib. J Clin Biochem Nutr. 2016 May;58(3):202-9. doi: 10.3164/jcbn.15-127. Epub 2016 Mar 15.

2016

ASHF, 高胆固醇，高胆酸钠

NASH,非酒精性脂肪肝

LE Gomez-Quiroz, D Seo, YH Lee, M Kitade, T Gaiser…. Loss of c-Met signaling sensitizes hepatocytes to lipotoxicity and induces cholestatic liver damage by aggravating oxidative stress.Toxicology. 2016 Jun 15;361-362:39-48. doi: 10.1016/j.tox.2016.07.004. Epub 2016 Jul 6.

2017

MCD（519541）, HF (519567）

NASH,非酒精性脂肪肝

Joseph A. Cichocki, Shinji Furuya, Kranti Konganti, Yu-Syuan Luo, Thomas J. McDonald, Yasuhiro Iwata, Weihsueh A. Chiu, David W. Threadgill, Igor P. Pogribny, Ivan Rusyn. Impact of nonalcoholic fatty liver disease on toxicokinetics of tetrachloroethylene in mice. J Pharmacol Exp Ther. 2017 Apr;361(1):17-28. doi: 10.1124/jpet.116.238790. Epub 2017 Feb 1.

2017

MCD（519541）, HF (519567）

NASH,非酒精性脂肪肝

Joseph A. Cichocki*, Shinji Furuya*, YuSyuan Luo*, Yasuhiro Iwata*, Kranti Konganti?,  Weihsueh A. Chiu*, David W. Threadgill?,?, Igor P. Pogribny§, Ivan Rusyn*,+ Nonalcoholic fatty liver disease is a susceptibility factor for perchloroethylene-induced liver effects in mice.Toxicological Sciences, Volume 159, Issue 1, 1 September 2017, Pages 102–113

2017

MCD, MCS

NASH,非酒精性脂肪肝

NaokiTanaka,ShogoTakahashi,XiaoHu,LuYu,NaoyukiFujimori,SrujanaGolla,Zhong-ZeFang,ToshifumiAoyama,Kristopher W. Krausz, Frank J. Gonzalez.Growth arrest and DNA damage-inducible 45αprotects against nonalcoholic steatohepatitis induced by methionine-andcholine-deficient diet.Biochim Biophys Acta. 2017 Dec;1863(12):3170-3182.

2017

MCD, MCS

NASH,非酒精性脂肪肝

Sou Hyun Kim1,#, Yong Lim2,#, Ju Bin Park2, Jae-Hwan Kwak3, Keuk-Jun Kim4, Joung-Hee Kim4,HyunKeun Song5, Joon Young Cho6, Dae Youn Hwang7, Kil Soo Kim8, Young-Suk Jung1,* Comparative study of fatty liver induced by methionine and choline-deficiency in C57BL/6N mice originating fromthree different sources.Lab Anim Res 2017: 33(2), 157-164

2017

MCD, HF （112280）

NASH,非酒精性脂肪肝

JianHuaHan1,2,AnikaL.Dzierlenga1,ZhengqiangLu3,DeanD.Billheimer3,ElmiraTorabzadeh3,AprilD.Lake1,HuiLi1,PetrNovak4,PetiaShipkova5,NellyAranibar5,DonaldRobertson5,MichaelD.Reily5,LoisD.Lehman-McKeeman5,andNathanJ.Cherrington. Metabolomic Profiling Distinction of Human Nonalcoholic Fatty Liver Disease Progression from a Common Rat Model. Obesity|VOLUME00|NUMBER00|MONTH2017

2017

MCD

NASH,非酒精性脂肪肝

HyoJeongKima,1,YeonsooJoea,1,Seul-KiKima,Se-UngParka,JeongminParka,YingqingChena,JinKima,JinhyunRyub,GyeongJaeChob,Young-JoonSurhc,StefanW.Ryterd,Uh-HyunKime,?,Hun-TaegChunga,Carbon monoxide protects against hepatic steatosis in mice by inducing sestrin-2 via the PERK-eIF2α-ATF4 pathway.Free Radical Biology and Medicine 110 (2017) 81–91

2016

MCD, MCS

NASH,非酒精性脂肪肝

H Li, JD Clarke, AL Dzierlenga, J Bear,NathanJ.Cherrington.In vivo cytochrome P450 activity alterations in diabetic nonalcoholic steatohepatitis mice. J Biochem Mol Toxicol2016;00:1–9

2017

MCD,CDAA

NASH,非酒精性脂肪肝

MJ Lyall, J Cartier, JA Richards,Diego Cobice,John P Thomson,Richard R Meehan,Stephen M Anderton,Amanda J Drake.Methyl donor deficient diets cause distinct alterations in lipid metabolism but are poorly representative of human NAFLD. Wellcome Open Research 2017, 2:67